Mulberry seeds perform high hypoglycaemic effect partially by inhibition of a-glucosidase activity

نویسندگان

  • Li Wang
  • Xiaodi Wang
  • Qunhui Wang
چکیده

Mulberry is one of the Chinese traditional medicines. But few studies focused on the hypoglycemic effect of Mulberry seed and the possible mechanisms. We identified that mulberry seed is rich in DNJ, the content of which is 0.6015%. Both mulberry seeds powder and its aqueous extract were used to detect the hypoglycemic effect of mulberry seeds. The results indicated that mulberry seeds powder could reduce the FBG, PBG and HbA1c, and abate the organ injuries such as liver, kidney and spleen of diabetic mice. The results also showed that aqueous extract of mulberry seed powder orally to diabetic mice significantly improved the glucose tolerance of mice, and the mulberry seeds aqueous extract significantly inhibited the activity of sucrase and maltase in vitro. These suggested that Mulberry seeds perform high hypoglycemic effect by inhibition of α-glucosidase activity.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Inhibitory Effects of Swietenia Mahagoni Seeds Extract on Α-Glucosidase and Α-amylase

This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays.  Swietenia mahagoni seeds were extracted by using Supercritical Carbon Dioxide (SC-CO2) extraction at pressures of 20- 30 MPa and temperatures of 40- 60°C.  The oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays.  A...

متن کامل

Hypoglycaemic effects of chloroformic, ethanolic and hydroalcoholic extracts of Trigonella foenum-graecum L. seeds (fenugreek) on diabetic rats

Trigonella foenum-gracum L. (Fenugreek) (Leguminosae) is employed as an herbal medicine. Its seeds are known for their carminative, tonic and antidiabetic effects. In the present study, we investigated the hypoglycaemic activities of the hydroalcoholic, ethanolic and chloroformic extracts of the Trigonella foenum-gracum seeds in streptozotocin-diabetic rats using interperitoneall (i.p.) adminis...

متن کامل

Hypoglycaemic effects of chloroformic, ethanolic and hydroalcoholic extracts of Trigonella foenum-graecum L. seeds (fenugreek) on diabetic rats

Trigonella foenum-gracum L. (Fenugreek) (Leguminosae) is employed as an herbal medicine. Its seeds are known for their carminative, tonic and antidiabetic effects. In the present study, we investigated the hypoglycaemic activities of the hydroalcoholic, ethanolic and chloroformic extracts of the Trigonella foenum-gracum seeds in streptozotocin-diabetic rats using interperitoneall (i.p.) adminis...

متن کامل

IN VITRO STUDY OF THE EFFECT OF THYMUS VULGARIS ON ALPHA-GLUCOSIDASE ENZYME INHIBITION FOR TREATING DIABETES

Background: Diabetes is a metabolic abnormality in the body caused by the high activity of the α-glucosidase enzyme in the hydrolysis of carbohydrates to glucose. Alpha-glucosidase inhibitors involved in the digestion of carbohydrates, play a key role in controlling diabetes. Thymus vulgaris is a species of flowering plant in the mint family Lamiaceae with a chromosome number of 2n = 30. The es...

متن کامل

Helianthus annuus Leaf Ameliorates Postprandial Hyperglycaemia by Inhibiting Carbohydrate Hydrolyzing Enzymes Associated with Type-2 Diabetes

Background: Diabetes mellitus is a chronic disease. Decreasing postprandial hyperglycemia by retarding glucose absorption through inhibiting carbohydrates digesting enzymes (α-amylase and α-glucosidase) is one of many approaches used for the management of this disease. This study was aimed at evaluating the normoglycaemic potential of Helianthus annuus leaf. Methods: The effect o...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017